Exercise Lowers Risk for Colon Cancer
Obesity increases a person’s risk for a certain type of colorectal cancer, while exercise lowers the risk, according to a new study.
Researchers analyzed data of men and women from Health Professionals Study and U.S. Nurses’ Health Study. The aim of the study was to find out if there was a link between the weight or BMI (body mass index), exercise or physical activity and the risk for CTNNB1 (a molecule implicated in cancer and obesity)-positive or CTNNB1-negative colorectal cancer.
According to findings published in the journal Cancer Research, BMI and physical activity have no impact on the risk for CTNNB1 –positive colorectal cancer. On the other hand, a higher BMI (body fat measurement based on weight and height) was linked to an increased risk of CTNNB1 –negative colorectal cancer while physical activity was linked to lower risk.
The results of the study provide additional evidence for a causal role of obesity and lack of physical activity in a specific molecular subtype of colorectal cancer, according to Dr. Shuji Ogino, associate professor of pathology at Dana-Farber Cancer Institute and an associate professor in the department of epidemiology at Harvard School of Public Health.
Likewise, Ogino said that the findings suggest that the CTNNB1 molecule could be a potential target for drugs for the prevention and treatment of colorectal cancer in some patients.
Ogino added that if doctors were able to identify individuals who are more likely to develop CTNBB1 –negative colorectal cancer, physical activity would then be strongly recommended.
HealthDay News. Obesity, Exercise May Affect Risk for Key Type of Colon Cancer.